Essential cellular behaviors, including those that ensure its survival or homeostasis, are modulated by many intrinsic or extrinsic factors. For the last few decades, efforts have been ongoing to identify these factors, followed by their functional characterization, ultimately leading to decoding these complex response mechanisms. Despite years of experimentation involving heating, boiling, freezing, and electroporation of cells, our understanding of how these chemical moieties influence vital fundamental cellular processes is far from complete.
The Ahuja Lab at IIIT-Delhi uses a hybrid approach involving Artificial Intelligence and Molecular Biology. Some of the long-term projects of the lab include:
Decoding logics: Using Artificial Intelligence & Yeast-based sensors
Our lab has recently compiled a compendium of the GPCR-drug database and developed a novel language-based Deep Learning architecture to understand the rules of Drug-Target interaction.
Connecting Dots: Linking metabolites to cell-cell communication
This project leverages the combo of Protein Language Models and cheminformatics to link receptor proteins involved in cell-cell communications to tissue-associated, extracellular metabolic landscape.
Ultimate Response: Decrypting interactions between chemical & biological space
Comprehensive mechanistic insights into biological systems necessitate a thorough evaluation of each node of the underlying multi-dimensional processes and their interdependence. Inspired by Graph Theory Algorithms, we are attempting to dissect this highly convulated networks, and validating our computational findings using Yeast-based assays.
Cellular Ethology: Defining Grammar of Induced Cellular Behavior
We are presently developing microfluidics-based cell behavior assays to monitor the impact of bioactive compounds on cellular behaviors.
Current Students
Alumni
The Ahuja lab is supported by the Ramalingaswami Re-entry Fellowship, a re-entry scheme of the Department of Biotechnology (DBT), Ministry of Science & Technology, Govt. of India, and an Intramural Start-up grant from Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi). The lab has also been awarded funding from Science and Engineering Research Board (SERB) for promoting basic research in Science and Engineering.